Spider-Man Vs. Dracula reprints the story “Ship of Fools” from Amazing Spider-Man Giant-Size #1. Aunt May is dying of a new strain of flu. The only known cure for this flu is a vaccine that had just been discovered by Dr. A.J. Maxwell, who is now carrying it to America. Unfortunately, Dr. Maxwell is an eccentric who refuses to travel except by boat. As a result, the vaccine may arrive too late to save Aunt May. As Spider-Man, Peter borrowed a jump jet from the Fantastic Four and is going to expedite Maxwell’s trip. Who could guess, though, that there is another already aboard the boat who seeks to destroy Maxwell’s vaccine—Dracula himself!