A vampire serial killer, known as the Boston Butcher, is tearing victims apart all over the city. The Boston Butcher tries to feed on a priest, Michael O’Reilly, and the Butcher finds that his victim's blood burns.

O'Reilly dies, becomes a vampire, and a guardian angel appears, transforming him into a crusading warrior known as Shadow Cross.

Shadow Cross will need all of his heavenly powers, as well as his vampiric strength, to face the evil foes.