Anna Mandretta is a young woman on a submarine-like vessel submerged in the waters of an alien moon. By night, she dreams the life of an alternate reality, in which she is an acclaimed surgeon at the Miskatonik University Hospital. Unable to save the life of an infant inflicted with a hideous, hissing tumor, she is assaulted by the boy's parents, who claim he will be reborn to eternal life to rule the world in the name of an ancient deity, Azag-thoth. This gothic space fantasy follows Anna as she shifts between her horrific reality as a medic on the front lines of a war against the mysterious Xax, and the supernatural life she leads in the recurring dream that draws closer to becoming her waking world.